Alliacane-Type Secondary Metabolites from Submerged Cultures of the Basidiomycete Clitocybe nebularis
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| Schrey_Alliacane-type Secondary Metabolites from Submerged Cultures of the Basidiomycete Clitocybe nebularis_2022_submitted-version.pdf | 1.27 MB | Adobe PDF | View/Open |
| Authors: | Schrey, Hedda  Scheele, Tarek Ulonska, Conrad Nedder, Dana Leoni Neudecker, Tim Spiteller, Peter Stadler, Marc |
Abstract: | Seven sesquiterpenoids, named nebucanes A–G (1–7), featuring a rare alliacane scaffold with unprecedented furan or pyrrole functions, were isolated from the fermentation broth of Clitocybe nebularis. Their structures were established on the basis of 1D/2D NMR spectroscopic analyses, HR-(+)-ESIMS spectra, and comparison of measured and calculated CD spectra for determination of the absolute configuration. Assessing the biological activities, nebucane D (4) exhibited antifungal effects against Rhodotorula glutinis, while nebucane G (7) displayed significant cytotoxicity against MCF-7 and A431 cell lines. |
Keywords: | Absolute configuration; Carbon; Chemical structure; Circular dichroism spectroscopy; Sesquiterpenoids | Issue Date: | 21-Sep-2022 | Publisher: | American chemical society | Journal/Edited collection: | Journal of Natural Products | Issue: | 10 | Start page: | 2363 | End page: | 2371 | Volume: | 85 | Type: | Artikel/Aufsatz | ISSN: | 0163-3864 | Secondary publication: | yes | Document version: | Preprint | DOI: | 10.26092/elib/3678 | URN: | urn:nbn:de:gbv:46-elib87695 | Institution: | Universität Bremen | Faculty: | Fachbereich 02: Biologie/Chemie (FB 02) Zentrale Wissenschaftliche Einrichtungen und Kooperationen |
Institute: | Institut für Physikalische und Theoretische Chemie MAPEX Center for Materials and Processes |
| Appears in Collections: | Forschungsdokumente |
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