Alliacane-Type Secondary Metabolites from Submerged Cultures of the Basidiomycete Clitocybe nebularis
Veröffentlichungsdatum
2022-09-21
Zusammenfassung
Seven sesquiterpenoids, named nebucanes A–G (1–7), featuring a rare alliacane scaffold with unprecedented furan or pyrrole functions, were isolated from the fermentation broth of Clitocybe nebularis. Their structures were established on the basis of 1D/2D NMR spectroscopic analyses, HR-(+)-ESIMS spectra, and comparison of measured and calculated CD spectra for determination of the absolute configuration. Assessing the biological activities, nebucane D (4) exhibited antifungal effects against Rhodotorula glutinis, while nebucane G (7) displayed significant cytotoxicity against MCF-7 and A431 cell lines.
Schlagwörter
Absolute configuration
;
Carbon
;
Chemical structure
;
Circular dichroism spectroscopy
;
Sesquiterpenoids
Verlag
American chemical society
Institution
Institute
Institut für Physikalische und Theoretische Chemie
Dokumenttyp
Wissenschaftlicher Artikel
Zeitschrift/Sammelwerk
Band
85
Heft
10
Startseite
2363
Endseite
2371
Zweitveröffentlichung
Ja
Dokumentversion
Preprint
Lizenz
Alle Rechte vorbehalten
Sprache
Englisch
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Name
Schrey_Alliacane-type Secondary Metabolites from Submerged Cultures of the Basidiomycete Clitocybe nebularis_2022_submitted-version.pdf
Size
1,24 MB
Format
Adobe PDF
Checksum
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