Horn, Matthias
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Horn, Matthias
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Horn, Matthias
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Horn, M.
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Item-typ:Veröffentlichung, Strain diversity and evolution in endosymbionts of Bathymodiolus mussels(2019-03-26); ; ; Accumulating evidence shows that closely related strains of the same bacterial species can differ strongly in their functions. However, in intimate symbioses between bacteria and animal hosts, the impact of strain-level diversity is largely unexplored. Evolutionary theory predicts that mutualistic symbioses, should be destabilized by genetic diversity among closely-related symbiont strains. Yet, to date it is unknown if this prediction holds true in environmental symbioses. In this thesis I therefore aimed to deepen our current understanding of mutualistic symbioses, and the potential role that symbiont strain diversity and evolution may play in it. To do so, I performed high-resolution genomic analyses of the endosymbionts of Bathymodiolus mussels. My findings challenge and extent current evolutionary theories and point out the value of in-depth analysis of environmental bacterial communities to deepen our understanding of evolution, microbial interaction and symbiosis.Dissertation357 195 - Some of the metrics are blocked by yourconsent settings
Item-typ:Veröffentlichung, Molecular biology and evolution of the bacterial intranuclear parasite Ca. Endonucleobacter(2020-11-24); ; ; Few bacteria are able to colonize eukaryotic host cells, and even fewer can invade organelles. Among the latter, those which colonize the nucleus (intranuclear bacteria) are a majority. The nucleus is considered as a replication niche that offers bacteria shelter, the opportunity to manipulate nuclear processes and nutrients in form of chromatin. Previous studies have suggested that intranuclear bacteria consume host chromatin, but this would inevitably lead to a collapse of their replication niche. Nuclear colonization has intrinsic risks for bacteria, as eukaryotic cells are able to sense nuclear deformation and respond to it activating apoptosis. Therefore, intranuclear bacteria must count on molecular mechanisms to prevent their host cells to shut down. Although many intranuclear bacteria have been visually characterized, little is known about how they colonize the nucleus, how they thrive within, and which effects they have on their host cells. [...] My findings challenge previous hypotheses about nutritional and survival strategies of intranuclear bacteria, and point out the genomic innovations that might define intranuclear lifestyle in bacteria.Dissertation308 267