Nörtersheuser, Peter
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Nörtersheuser, Peter
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Nörtersheuser, Peter
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Item-typ:Veröffentlichung, Schätzung der Input- und Response-Funktion bei numerischer Konvolution und Dekonvolution im Rahmen pharmakokinetischer UntersuchungenA numerical procedure for convolution and deconvolution of pharmacokinetic data is looked at as a statistical estimation problem. Estimators for the input-and response function based on a point-area convolution method are derived and their asymptotical properties are discussed. Several approaches to estimate the asymptotic variance of the estimators including jackknife and bootstrap techniques are discussed. A simulation study to investigate the finite sample performance of the estimators is presented.Dissertation242 190