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  4. Functional Implications of Synaptic Spike Timing Dependent Plasticity and Anti-Hebbian Membrane Potential Dependent Plasticity
 
Zitierlink URN
https://nbn-resolving.de/urn:nbn:de:gbv:46-00104657-17

Functional Implications of Synaptic Spike Timing Dependent Plasticity and Anti-Hebbian Membrane Potential Dependent Plasticity

Veröffentlichungsdatum
2015-07-15
Autoren
Albers, Christian  
Betreuer
Pawelzik, Klaus  
Gutachter
Bornholdt, Stefan  
Zusammenfassung
A central hypothesis of neuroscience is that the change of the strength of synaptic connections between neurons is the basis for learning in the animal brain. However, the rules underlying the activity dependent change as well as their functional consequences are not well understood. This thesis develops and investigates several different quantitative models of synaptic plasticity. In the first part, the Contribution Dynamics model of Spike Timing Dependent Plasticity (STDP) is presented. It is shown to provide a better fit to experimental data than previous models. Additionally, investigation of the response properties of the model synapse to oscillatory neuronal activity shows that synapses are sensitive to theta oscillations (4-10 Hz), which are known to boost learning in behavioral experiments. In the second part, a novel Membrane Potential Dependent Plasticity (MPDP) rule is developed, which can be used to train neurons to fire precisely timed output activity. Previously, this could only be achieved with artificial supervised learning rules, whereas MPDP is a local activity dependent mechanism that is supported by experimental results.
Schlagwörter
Neuronal networks

; 

synaptic plasticity

; 

STDP

; 

theta oscillations

; 

learning

; 

memory

; 

associative learning
Institution
Universität Bremen  
Fachbereich
Fachbereich 01: Physik/Elektrotechnik (FB 01)  
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Englisch
Dateien
Lade...
Vorschaubild
Name

00104657-1.pdf

Size

8.47 MB

Format

Adobe PDF

Checksum

(MD5):e2ac6dd13a20518572fc35a6fad57604

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