Supercritical CO2 deposition and foaming process for fabrication of biopolyester–ZnO bone scaffolds
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Subsequent supercritical CO2-assisted deposition and foaming process followed by in situ synthesis was used to fabricate functional polylactide (PLA) and polylactide–poly(E-caprolactone) (PLA–PCL) bone scaffolds. Deposition of zinc bis(2-thenoyltri-
fluoroacetonate) as a ZnO precursor onto biopolyester substrates (30 MPa; 110 8C) was followed by fast depressurization to create cellular structure. Contact time was optimized regarding the deposition yield (2 h), while PCL content in PLA was varied (1–10 wt %).
Scaffolds impregnated with the precursor were treated with hydrazine alcoholic solution to obtain biopolyester–ZnO composites. Precursor synthesis and deposition onto the scaffolds was confirmed by Fourier-transform infrared. Processed scaffolds had micron-sized pores (d50 20 lm). High open porosity (69–77%) and compressive strength values (2.8–8.3 MPa) corresponded to those reported for trabecular bone. PLA blending with PCL positively affected precursor deposition, crystallization rate, and compressive strength of the scaffolds. It also improved PLA surface roughness and wettability which are relevant for cell adhesion. ZnO improved compressive strength of the PLA scaffolds without significant effect on thermal stability. Analysis of structural, thermal, and mechanical properties of biopolyester–ZnO scaffolds testified a great potential of the obtained platforms as bone scaffolds. Proposed processing route is
straightforward and ecofriendly, fast, easy to control, and suitable for processing of thermosensitive polymers.
|Keywords:||biomedical applications; biopolymers and renewable polymers; composites; foams||Issue Date:||15-Feb-2018||Publisher:||Wiley||Project:||Ministry of Education, Sci- ence and Technological Development of the Republic of Serbia
DAAD Funding Program Research Stays for University Academics and Scientists
|Grant number:||III 45017
|Journal/Edited collection:||Journal of Applied Polymer Science||Start page:||1||End page:||11||Note:||7||Band:||135||Pages:||11||Type:||Artikel/Aufsatz||ISSN:||0021-8995||Secondary publication:||yes||Document version:||Postprint||DOI:||10.26092/elib/2627||URN:||urn:nbn:de:gbv:46-elib73933||Institution:||Universität Bremen||Faculty:||Fachbereich 04: Produktionstechnik, Maschinenbau & Verfahrenstechnik (FB 04)||Institute:||Fachgebiet 17: Keramische Werkstoffe und Bauteile|
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checked on Dec 9, 2023
checked on Dec 9, 2023
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