Effect of divalent versus monovalent cations on the MS2 retention capacity of amino-functionalized ceramic filters
|J. Bartels, N. Hildebrand, M. Nawrocki, S. Kroll, M. Maas, L. Colombi Ciacchi, K. Rezwan, Effect of divalent versus monovalent cations_2018_accepted version.pdf||2.97 MB||Adobe PDF||View/Open|
Hildebrand, Nils Alexander
Colombi Ciacchi, Lucio
Ceramic capillary membranes conditioned for virus filtration via functionalization with n-(3-trimethoxysilylpropyl)diethylenetriamine (TPDA) are analyzed with respect to their virus retention capacity when using feed solutions based on monovalent and divalent salts (NaCl, MgCl2). The log reduction value (LRV) by operating in dead-end mode using the model bacteriophage MS2 with a diameter of 25 nm and an IEP of 3.9 is as high as 9.6 when using feeds containing MgCl2. In contrast, a lesser LRV of 6.4 is observed for feed solutions based on NaCl. The TPDA functionalized surface is simulated at the atomistic scale using explicit-solvent molecular dynamics in the presence of either Na+ or Mg2+ ions. Computational prediction of the binding free energy reveals that the Mg2+ ions remain preferentially adsorbed at the surface, whereas Na+ ions form a weakly bound dissolved ionic layer. The charge shielding between surface and amino groups by the adsorbed Mg2+ ions leads to an upright orientation of the TPDA molecules as opposed to a more tilted orientation in the presence of Na+ ions. The resulting better accessibility of the TPDA molecules is very likely responsible for the enhanced virus retention capacity using a feed solution with Mg2+ ions.
|Keywords:||Mimenima||Issue Date:||10-Apr-2018||Publisher:||Royal Society of Chemistry||Project:||MIMENIMA GRK 1860||Funders:||Deutsche Forschungsgemeinschaft||Grant number:||601090||Journal/Edited collection:||Physical chemistry chemical physics : PCCP||Start page:||11215||End page:||11223||Note:||16||Band:||20||Pages:||9||Type:||Artikel/Aufsatz||Secondary publication:||yes||Document version:||Postprint||DOI:||10.26092/elib/2488||URN:||urn:nbn:de:gbv:46-elib71674||Institution:||Universität Bremen||Faculty:||Fachbereich 04: Produktionstechnik, Maschinenbau & Verfahrenstechnik (FB 04)||Institute:||Zentrum für Umweltforschung und nachhaltige Technologien (UFT)
MAPEX Center for Materials and Processes
Faserinstitut Bremen e.V. (FIBRE)
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checked on Nov 28, 2023
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