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Citation link: https://doi.org/10.26092/elib/2368

Publisher DOI: https://doi.org/10.1038/nature20778
Hirose-Wright-et-al_Lifespan effects of mitochondrial mutations_2017_accepted version_PDF-A.pdf
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Lifespan effects of mitochondrial mutations


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Authors: Hirose, Misa  
Schilf, Paul  
Gupta, Yask 
Wright, Marvin N.  
Jöhren, Olaf  
Wagner, Anika  
Sina, Christian 
Ziegler, Andreas  
Ristow, Michael  
Ibrahim, Saleh M 
Abstract: 
Somatic mitochondrial DNA (mtDNA) mutations accumulate within various tissues with age, however evidence directly showing the influence of mtDNA natural variations on ageing has been limited to date. Recently, Latorre-Pellicer et al. demonstrated that polymorphisms within mtDNA affect reactive oxygen species (ROS) levels, body mass, ageing score, tumour incidence and lifespan of conplastic mice. Here we show that similarly generated conplastic strains, which carry a nuclear Nnt mutation, do not show any alterations in these parameters, demonstrating the relevance of specific mitonuclear interactions in determining mammalian healthspan through increased production of ROS.
Keywords: Somatic mitochondrial DNA; Genetics research; Geriatrics; Mitochondrial genome; Senescence
Issue Date: 14-Dec-2016
Publisher: Springer Nature
Journal/Edited collection: Nature 
Type: Artikel/Aufsatz
ISSN: 0028-0836
Secondary publication: yes
Document version: Postprint
DOI: 10.26092/elib/2368
URN: urn:nbn:de:gbv:46-elib70477
Institution: andere Institution 
Appears in Collections:Forschungsdokumente

  

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