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  4. Atomic force microscopy for cell mechanics and diseases
 
Zitierlink DOI
10.26092/elib/508
Verlagslink DOI
10.1515/nf-2020-0001

Atomic force microscopy for cell mechanics and diseases

Veröffentlichungsdatum
2020-04-22
Autoren
Perez-Dominguez, Sandra  
Kulkarni, Shruti G.  
Rianna, Carmela  
Herausgeber
Radmacher, Manfred  
Zusammenfassung
Atomic Force Microscopy (AFM) is a powerful technique widely employed in biophysics, for instance to study topography of living cells and cell mechanics. Cell mechanics is a very interesting, biophysical parameter of cells, because it is strongly changed by various cellular processes, for example during cell division, cell movement, differentiation, aging, and also various diseases. Since cancer is a prominent example of changes in mechanical properties of diseases, the concept of the mechanical fingerprint has developed, which makes it possible to distinguish between healthy and diseased cells. In this article we report on various studies of cell mechanics with the AFM. We will first give a brief introduction on AFM principles and operational modes and then we will report on some applications of AFM in the field of cellular biophysics, like discriminating between healthy and cancer cells, as well as distinguishing cancer cells at different stages of malignancy. Overall, we will show that AFM has made a significant contribution in studying the biophysics of cancer and the concept of mechanical fingerprints could find a wide variety of applications in biomedicine and medical diagnostics.
Schlagwörter
Atomic Force Microscopy (AFM)

; 

Biophysics

; 

Diseases

; 

Cancer

; 

Cell mechanics
Institution
Universität Bremen  
Fachbereich
Fachbereich 01: Physik/Elektrotechnik (FB 01)  
Institute
Institut für Biophysik  
Dokumenttyp
Artikel/Aufsatz
Zweitveröffentlichung
Nein
Sprache
Englisch
Dateien
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Vorschaubild
Name

2020 - Neuroforum Atomic force microscopy for cell mechanics and diseases.pdf

Size

879.51 KB

Format

Adobe PDF

Checksum

(MD5):aaedefb19ed12457935c90ea1e8c4820

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