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Citation link: http://nbn-resolving.de/urn:nbn:de:gbv:46-diss000119768
00011976.pdf
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Identifizierung unbekannter Funktionen im Lassa-Virus L-Protein


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00011976.pdf10.99 MBAdobe PDFView/Open
Other Titles: Identification of unknown functions in Lassa virus L protein
Authors: Lelke, Michaela 
Supervisor: Günther, Stephan
1. Expert: Dotzauer, Andreas
2. Expert: Günther, Stephan
Abstract: 
The central domain of the 200-kDa Lassa virus L protein is a putative RNA-dependent RNA polymerase. N- and C-terminal domains may harbor enzymatic functions important for viral mRNA synthesis, including capping enzymes or cap-snatching endoribonucleases. In this work it was shown that the N-terminal region in L protein is important for mRNA, but not for genome synthesis. Bioinformatics and cell biological experiments lend support to the hypothesis that this region could be part of a cap-snatching enzyme.
Keywords: Lassa virus, endonuclease, capping
Issue Date: 1-Jul-2010
Type: Dissertation
URN: urn:nbn:de:gbv:46-diss000119768
Institution: Universität Bremen 
Faculty: FB2 Biologie/Chemie 
Appears in Collections:Dissertationen

  

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