Identifizierung unbekannter Funktionen im Lassa-Virus L-Protein
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Other Titles: | Identification of unknown functions in Lassa virus L protein | Authors: | Lelke, Michaela | Supervisor: | Günther, Stephan | 1. Expert: | Dotzauer, Andreas | Experts: | Günther, Stephan | Abstract: | The central domain of the 200-kDa Lassa virus L protein is a putative RNA-dependent RNA polymerase. N- and C-terminal domains may harbor enzymatic functions important for viral mRNA synthesis, including capping enzymes or cap-snatching endoribonucleases. In this work it was shown that the N-terminal region in L protein is important for mRNA, but not for genome synthesis. Bioinformatics and cell biological experiments lend support to the hypothesis that this region could be part of a cap-snatching enzyme. |
Keywords: | Lassa virus; endonuclease; capping | Issue Date: | 1-Jul-2010 | Type: | Dissertation | Secondary publication: | no | URN: | urn:nbn:de:gbv:46-diss000119768 | Institution: | Universität Bremen | Faculty: | Fachbereich 02: Biologie/Chemie (FB 02) |
Appears in Collections: | Dissertationen |
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