Identifizierung unbekannter Funktionen im Lassa-Virus L-Protein
Veröffentlichungsdatum
2010-07-01
Autoren
Betreuer
Gutachter
Zusammenfassung
The central domain of the 200-kDa Lassa virus L protein is a putative RNA-dependent RNA polymerase. N- and C-terminal domains may harbor enzymatic functions important for viral mRNA synthesis, including capping enzymes or cap-snatching endoribonucleases. In this work it was shown that the N-terminal region in L protein is important for mRNA, but not for genome synthesis. Bioinformatics and cell biological experiments lend support to the hypothesis that this region could be part of a cap-snatching enzyme.
Schlagwörter
Lassa virus
;
endonuclease
;
capping
Institution
Fachbereich
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Deutsch
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