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  4. Interactions of serotonin2A and metabotropic glutamate2/3 receptors in behavioural control in rats
 
Zitierlink URN
https://nbn-resolving.de/urn:nbn:de:gbv:46-00102519-11

Interactions of serotonin2A and metabotropic glutamate2/3 receptors in behavioural control in rats

Veröffentlichungsdatum
2011-12-13
Autoren
Wischhof, Lena  
Betreuer
Koch, Michael  
Gutachter
Dicke, Ursula  
Zusammenfassung
Serotonin (5-hydroxytryptamine, 5-HT)2A and metabotropic glutamate (mGlu2/3) receptors show a strikingly overlapping distribution and share strong behavioural and functional interactions. The thesis investigated the functional relevance of 5-HT2A and mGlu2/3 receptor interactions focussing on two aspects of behavioural inhibition: impulsivity and sensorimotor gating mechanisms. Experiments were conducted in Lister Hooded rats trained in different tests for impulsivity and treated with 5-HT2A and mGlu2/3 receptor ligands. Sensorimotor gating mechanisms were assessed via the prepulse inhibition of the acoustic startle reflex. Taken together, the studies show close antagonistic interactions between 5-HT2A and mGlu2/3 receptors at the behavioural and systems level. The results further suggest that mGlu2/3 receptor agonists have the potential to attenuate impulsivity-related disorders and sensorimotor gating deficits resulting from a hyperserotonergic state.
Schlagwörter
Impulsivity

; 

schizophrenia

; 

prepulse inhibition

; 

5-choice serial reaction time task

; 

delayed-reward task
Institution
Universität Bremen  
Fachbereich
Fachbereich 02: Biologie/Chemie (FB 02)  
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Englisch
Dateien
Lade...
Vorschaubild
Name

00102519-1.pdf

Size

6.88 MB

Format

Adobe PDF

Checksum

(MD5):fb7ec9871b1a36ba3b6584620c5bac1b

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