Interactions of serotonin2A and metabotropic glutamate2/3 receptors in behavioural control in rats
|Other Titles:||Interaktion von Serotonin2A- und metabotropen Glutamat2/3-Rezeptoren bei der Verhaltenskontrolle von Ratten||Authors:||Wischhof, Lena||Supervisor:||Koch, Michael||1. Expert:||Koch, Michael||2. Expert:||Dicke, Ursula||Abstract:||
Serotonin (5-hydroxytryptamine, 5-HT)2A and metabotropic glutamate (mGlu2/3) receptors show a strikingly overlapping distribution and share strong behavioural and functional interactions. The thesis investigated the functional relevance of 5-HT2A and mGlu2/3 receptor interactions focussing on two aspects of behavioural inhibition: impulsivity and sensorimotor gating mechanisms. Experiments were conducted in Lister Hooded rats trained in different tests for impulsivity and treated with 5-HT2A and mGlu2/3 receptor ligands. Sensorimotor gating mechanisms were assessed via the prepulse inhibition of the acoustic startle reflex. Taken together, the studies show close antagonistic interactions between 5-HT2A and mGlu2/3 receptors at the behavioural and systems level. The results further suggest that mGlu2/3 receptor agonists have the potential to attenuate impulsivity-related disorders and sensorimotor gating deficits resulting from a hyperserotonergic state.
|Keywords:||Impulsivity, schizophrenia, prepulse inhibition, 5-choice serial reaction time task, delayed-reward task||Issue Date:||13-Dec-2011||URN:||urn:nbn:de:gbv:46-00102519-11||Institution:||Universität Bremen||Faculty:||FB2 Biologie/Chemie|
|Appears in Collections:||Dissertationen|
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