Interactions of serotonin2A and metabotropic glutamate2/3 receptors in behavioural control in rats
Veröffentlichungsdatum
2011-12-13
Autoren
Betreuer
Gutachter
Zusammenfassung
Serotonin (5-hydroxytryptamine, 5-HT)2A and metabotropic glutamate (mGlu2/3) receptors show a strikingly overlapping distribution and share strong behavioural and functional interactions. The thesis investigated the functional relevance of 5-HT2A and mGlu2/3 receptor interactions focussing on two aspects of behavioural inhibition: impulsivity and sensorimotor gating mechanisms. Experiments were conducted in Lister Hooded rats trained in different tests for impulsivity and treated with 5-HT2A and mGlu2/3 receptor ligands. Sensorimotor gating mechanisms were assessed via the prepulse inhibition of the acoustic startle reflex. Taken together, the studies show close antagonistic interactions between 5-HT2A and mGlu2/3 receptors at the behavioural and systems level. The results further suggest that mGlu2/3 receptor agonists have the potential to attenuate impulsivity-related disorders and sensorimotor gating deficits resulting from a hyperserotonergic state.
Schlagwörter
Impulsivity
;
schizophrenia
;
prepulse inhibition
;
5-choice serial reaction time task
;
delayed-reward task
Institution
Fachbereich
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Englisch
Dateien![Vorschaubild]()
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Name
00102519-1.pdf
Size
6.88 MB
Format
Adobe PDF
Checksum
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