Chronic toxicity of endocrine disrupters to the crustacean Daphnia magna under complex exposure situations
File | Description | Size | Format | |
---|---|---|---|---|
00011723.pdf | 3.18 MB | Adobe PDF | View/Open |
Other Titles: | Chronische Effekte endokrin wirksamer Substanzen auf Daphnia magna unter komplexen Expositionsbedingungen | Authors: | Hassold, Enken | Supervisor: | Backhaus, Thomas | 1. Expert: | Filser, Juliane | Experts: | Backhaus, Thomas | Abstract: | The aim of this thesis is to evaluate the chronic effects of endocrine disrupting chemicals (EDCs) to the crustacean Daphnia magna under complex exposure situations. It comprises four experimental studies, dealing with the toxicity of single substances as well as mixtures.It is evaluated whether additional life-history parameters, such as molting and embryo abnormalities, may indicate interferences of selected chemicals with ecdysteroid-related processes in the reproduction test with Daphnia magna improving an assessment of endocrine disrupters. A focus was set on structurally diverse demethylase inhibiting fungicides (DMIs), which were comparatively assessed with respect to their single substance toxicity as well as their joint toxicity to Daphnia magna. Here, the two concepts Concentration Addition (CA) and Independent Action (IA) were used to predict mixture toxicity based on single substance data across different endpoints and effect levels. The last experiment focused on the toxicity of binary combinations under conditions of sequential or simultaneous exposure and the predictive abilities of the two mixture toxicity concepts. |
Keywords: | endocrine disrupters; Daphnia magna; mixture toxicity; demethylase inhibiting fungicides; Bisphenol A; Cadmium; Simazine; Fenarimol; Prochloraz; Triadimefon; Pyrifenox; Triforine; time varying exposures; sequential; simultaneous; Concentration Addition; Independent Action; crustacean | Issue Date: | 2-Oct-2009 | Type: | Dissertation | Secondary publication: | no | URN: | urn:nbn:de:gbv:46-diss000117233 | Institution: | Universität Bremen | Faculty: | Fachbereich 02: Biologie/Chemie (FB 02) |
Appears in Collections: | Dissertationen |
Page view(s)
271
checked on Apr 2, 2025
Download(s)
141
checked on Apr 2, 2025
Google ScholarTM
Check
Items in Media are protected by copyright, with all rights reserved, unless otherwise indicated.