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Citation link: http://nbn-resolving.de/urn:nbn:de:gbv:46-diss000116538
00011653.pdf
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Untersuchungen zur Genetik von Speicheldrüsentumoren


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00011653.pdf2.35 MBAdobe PDFView/Open
Other Titles: Genetic Analyses of Salivary Gland Tumors
Authors: Fehr, Andre 
Supervisor: Bullerdiek, Jörn
1. Expert: Bullerdiek, Jörn
2. Expert: Stenman, Göran 
Abstract: 
We have analyze the recently for mucoepidermoid carcinoma (MEC) and Warthin's tumor (WAT) described gene fusion CRTC1-MAML2 for its diagnostic potential as biomarker and to find out if an aberrant HMGA2 expression level influence tumorgenesis of MECs. Our studies have shown that a CRTC1-MAML2 test is a powerful tool for diagnosis and prognosis of MECs. The fusion correlates with a low- or intermediate-grade of the tumor and is associated with a favorable prognosis. CRTC1-MAML2 negative tumors were mainly found in high-grade tumors and show a significant increased HMGA2 level. These data raise doubts about the correct classification of MECs into low-, intermediate- and high-grade tumors. In our opinion the present classification of MECs includes two subgroups: A huge group of "true-MECs" with the CRTC1-MAML2 fusion, with a moderate aggressiveness and furthermore a group of morphological heterogeneous tumors lacking this fusion and with an aberrantly high HMGA2 expression level.
Keywords: Mucoepidermoid carcinoma, Warthin's tumor, CRTC1-MAML2, HMGA2, molecular biomarker, prognostic significance
Issue Date: 26-Nov-2009
Type: Dissertation
URN: urn:nbn:de:gbv:46-diss000116538
Institution: Universität Bremen 
Faculty: FB2 Biologie/Chemie 
Appears in Collections:Dissertationen

  

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