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Zitierlink URN
https://nbn-resolving.de/urn:nbn:de:gbv:46-diss000116538

Untersuchungen zur Genetik von Speicheldrüsentumoren

Veröffentlichungsdatum
2009-11-26
Autoren
Fehr, Andre  
Betreuer
Bullerdiek, Jörn  
Gutachter
Stenman, Göran  
Zusammenfassung
We have analyze the recently for mucoepidermoid carcinoma (MEC) and Warthin's tumor (WAT) described gene fusion CRTC1-MAML2 for its diagnostic potential as biomarker and to find out if an aberrant HMGA2 expression level influence tumorgenesis of MECs. Our studies have shown that a CRTC1-MAML2 test is a powerful tool for diagnosis and prognosis of MECs. The fusion correlates with a low- or intermediate-grade of the tumor and is associated with a favorable prognosis. CRTC1-MAML2 negative tumors were mainly found in high-grade tumors and show a significant increased HMGA2 level. These data raise doubts about the correct classification of MECs into low-, intermediate- and high-grade tumors. In our opinion the present classification of MECs includes two subgroups: A huge group of "true-MECs" with the CRTC1-MAML2 fusion, with a moderate aggressiveness and furthermore a group of morphological heterogeneous tumors lacking this fusion and with an aberrantly high HMGA2 expression level.
Schlagwörter
Mucoepidermoid carcinoma

; 

Warthin's tumor

; 

CRTC1-MAML2

; 

HMGA2

; 

molecular biomarker

; 

prognostic significance
Institution
Universität Bremen  
Fachbereich
Fachbereich 02: Biologie/Chemie (FB 02)  
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Englisch
Dateien
Lade...
Vorschaubild
Name

00011653.pdf

Size

2.29 MB

Format

Adobe PDF

Checksum

(MD5):18be768be50b50584317078aa2ddba66

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