Molekulargenetische Untersuchung von Genen der Phase I- und Phase II-Enzyme bei Lungenemphysem

Abstract

To examine the risk of chronic obstructive pulmonary disease (COPD) associated with genetic polymorphism of glutathione-S-transferase genes (GMTM1, GSTM3, GSTT1, GSTP1), epoxides hydrolases (mEH) and the cytochrome P450 genes (CYP1A1 and CYP2D6) were studied by different PCR-methods in 125 patients with COPD and 264 healthy individuals. Individual susceptibility to COPD is likely to be modified by genotype for enzymes involved in the detoxification of xenobiotics. A relationship between COPD and CYP1A1*1*2B, CYP2D6*1*1 and mEH*3*3 (OR 1,72, CI 95%: 0,76-3,91; OR 1,49, CI 95%: 0,97-2,29; OR 1,74, CI 95%: 0,93-6,59) were not significant but smoker with CYP2D6*1*1 display a 9,16-fold higher risk of developing COPD. Also the genotypes of GSTM1*0*0, GSTT1*1*1, GSTP1*A*A und GSTM3*A*A (OR 1,56, CI 95%: 1,02-2,4; OR 1,58, CI 95%: 1,00-2,45; OR 2,54, CI 95%: ; OR 2,55, CI 95%) were associated with a higher risk. Otherwise the genotypes CYP1A1*1*2A and mEH*1*1 (OR 0,65, CI 95%: 0,28-1,48; OR 0,44, CI 95%: 0,26-0,75) deliver a significant protection of COPD.