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  4. Toxicologic and pharmacologic properties of the dodecaborate cluster: Synthetic, physical-chemical and biological studies
 
Zitierlink URN
https://nbn-resolving.de/urn:nbn:de:gbv:46-diss000115569

Toxicologic and pharmacologic properties of the dodecaborate cluster: Synthetic, physical-chemical and biological studies

Veröffentlichungsdatum
2009-06-12
Autoren
Schaffran, Tanja  
Betreuer
Gabel, Detlef  
Gutachter
Jastorff, Bernd  
Zusammenfassung
Different dodecaborate cluster containing substances are studied: low molecular weight anions used in ionic liquids and high molecular weight boron lipids which are interesting for boron neutron capture therapy. The dodecaborate cluster unit B12H122- exhibits properties of a pharmacophor and consequently causes certain pharmacological interactions. It is responsible for a firm binding to membrane surfaces due to interactions with the head groups of phosphatidylcholine lipids. Compounds containing the dodecaborate cluster adopt this unexpected behavior which is not known for other ionic species.Amphiphilic derivatives of the dodecaborate cluster cause a different pharmacologic effect than pure ionic substances. Depending on their lipophilic part they can react as detergent or can incorporate into existing membranes without any disturbances of the membrane. High molecular weight compounds induce pharmacological effects which are unexpected and so far not understood in molecular detail.
Institution
Universität Bremen  
Fachbereich
Fachbereich 02: Biologie/Chemie (FB 02)  
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Englisch
Dateien
Lade...
Vorschaubild
Name

00011556.pdf

Size

11.8 MB

Format

Adobe PDF

Checksum

(MD5):d4515e1b6e2fed2e2efdabd79f615279

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