Geschlechtsspezifische Unterschiede von Nutzen und Risiken medikamentöser Präventionsmaßnahmen der Koronaren Herzkrankheit - Systematischer Review zur wissenschaftlichen und genderspezifischen Evidenz von in Deutschland angewendeten Interventionen -
|Other Titles:||Gender-specific differences in benefit and risk of preventive pharmacological treatment for coronary heart disease Systematic review of gender- and evidence based quality of drug interventions used in Germany||Authors:||Müller, Veronika Elisabeth||Supervisor:||Kolip, Petra||1. Expert:||Glaeske, Gerd||Abstract:||
The objective of this systematic review was to develop criteria for gender sensitive research and to determine the gender specific evidence for drugs used in primary prevention of coronary heart disease in women. Gender related and EBM quality criteria for conducting clinical trials were collected and put together. The result was an instrument capable to detect gender bias as well as other systematic error that might flaw the results of clinical trials. The next step was a systematic literature search to retrieve trials studying the effects of drugs used in primary prevention of coronary heart disease. Trials were evaluated using the instrument constructed in step 1.Findings were much clearer for both genders when analyses was made gender specific. The treatment effects were more distinct in men whereas they could not be shown in women. When put together, the effect size was underestimated for men and overestimated for women. Conducting gender sensitive studies leads to a greater validity of the results for both, women and men.
|Keywords:||gender sensitive research, evidence based medicine, gender specific drug metabolism, women, coronary heart disease, drug use in primary prevention||Issue Date:||9-May-2007||URN:||urn:nbn:de:gbv:46-diss000109093||Institution:||Universität Bremen||Faculty:||FB11 Human- und Gesundheitswissenschaften|
|Appears in Collections:||Dissertationen|
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