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Citation link: http://nbn-resolving.de/urn:nbn:de:gbv:46-diss000103648
00010364.pdf
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The Development and Use of New Methods and Strategies for the Monitoring of Nephrotoxicity and the Study of Renal Physiology: Proteomics- and Metabonomics-based Studies


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Other Titles: Die Entwicklung und Anwendung neuer Methoden und Strategien fuer das 'Monitoring' von Nephrotoxizitaet und die Studie der Nierenphysiologie: Auf Proteom- und Metabonomanalyse basierende Studien
Authors: Klawitter, Jost 
Supervisor: Leibfritz, Dieter
1. Expert: Leibfritz, Dieter, Christians, Uwe 
Abstract: 
A Key for avoiding the negative effects of immunosuppressant caused nephropathy after transplantation is early detection. This study shows a set of biomarkers, which could serve for the early detection of nephrotoxicity. Systematic development of a new model enables for the evaluation of drug induced nephrotoxicity and could be used for the development of new drugs in an early phase. We found indicators for the drug induced formation of reactive oxygen species, which could be causing the toxicity. The NMR-based model correlated with the 8-isoprostaglandin-F2aplha levels and the glomerular filtration rates showing the trend in toxicity:control
Keywords: NMR, HPLC/MS, Metabonomics, Proteomics, cyclosporine, sirolimus, tacrolimus, nephrotoxicity
Issue Date: 20-Jun-2006
Type: Dissertation
URN: urn:nbn:de:gbv:46-diss000103648
Institution: Universität Bremen 
Faculty: FB2 Biologie/Chemie 
Appears in Collections:Dissertationen

  

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