Studien zur Synthese einer Modellverbindung für Tolyporphin K
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|Other Titles:||Studies to the synthesis of a model compound for Tolyporphin K||Authors:||Saez Diaz, Rosa Isabel||Supervisor:||Montforts, Franz-Peter||1. Expert:||Montforts, Franz-Peter||2. Expert:||Stohrer, Wolf-Dieter||Abstract:||
Since the isolation of Tolyporphin A from the pacific cyanobacterium Tolypothrix nodosa in 1992, ten further Tolyporphins named B to K have been identified. Whereas Tolyporphins A-J belong to the bacteriochlorin structural class, Tolyporphin K is the only chlorin among these natural products. These compounds deserve special interest because of their biological activity. Tolyporphins are multidrug resistance (MDR) reversal agents and show a potent photosensitizing activity against tumor cells.The aim of this work is the total synthesis of a model compound for Tolyporphin K. In our synthetic approach two routes (I and II) were envisaged based on four different building blocks A, B, C and D. The key difference between route I and II is the sequential order in which the monocyclic rings are linked together.The route I succesfully led to a tetracyclic compound, advanced precursor of Tolyporphin K.
|Keywords:||tolyporphin K, MDR, natural product, total synthesis||Issue Date:||5-Dec-2005||URN:||urn:nbn:de:gbv:46-diss000102630||Institution:||Universität Bremen||Faculty:||FB2 Biologie/Chemie|
|Appears in Collections:||Dissertationen|
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