Logo des Repositoriums
Zur Startseite
  • English
  • Deutsch
Anmelden
  1. Startseite
  2. SuUB
  3. Dissertationen
  4. Studien zur Synthese einer Modellverbindung für Tolyporphin K
 
Zitierlink URN
https://nbn-resolving.de/urn:nbn:de:gbv:46-diss000102630

Studien zur Synthese einer Modellverbindung für Tolyporphin K

Veröffentlichungsdatum
2005-12-05
Autoren
Saez Diaz, Rosa Isabel  
Betreuer
Montforts, Franz-Peter  
Gutachter
Stohrer, Wolf-Dieter  
Zusammenfassung
Since the isolation of Tolyporphin A from the pacific cyanobacterium Tolypothrix nodosa in 1992, ten further Tolyporphins named B to K have been identified. Whereas Tolyporphins A-J belong to the bacteriochlorin structural class, Tolyporphin K is the only chlorin among these natural products. These compounds deserve special interest because of their biological activity. Tolyporphins are multidrug resistance (MDR) reversal agents and show a potent photosensitizing activity against tumor cells.The aim of this work is the total synthesis of a model compound for Tolyporphin K. In our synthetic approach two routes (I and II) were envisaged based on four different building blocks A, B, C and D. The key difference between route I and II is the sequential order in which the monocyclic rings are linked together.The route I succesfully led to a tetracyclic compound, advanced precursor of Tolyporphin K.
Schlagwörter
tolyporphin K, MDR, natural product, total synthesis
Institution
Universität Bremen  
Fachbereich
Fachbereich 02: Biologie/Chemie (FB 02)  
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Deutsch
Dateien
Lade...
Vorschaubild
Name

00010263.pdf

Size

1.3 MB

Format

Adobe PDF

Checksum

(MD5):4d3bf164fd734b743b66c003d64bc9e5

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science

  • Datenschutzbestimmungen
  • Endnutzervereinbarung
  • Feedback schicken