Logo des Repositoriums
Zur Startseite
  • English
  • Deutsch
Anmelden
  1. Startseite
  2. SuUB
  3. Dissertationen
  4. Studien zur Synthese einer Modellverbindung für Tolyporphin A
 
Zitierlink URN
https://nbn-resolving.de/urn:nbn:de:gbv:46-diss000007618

Studien zur Synthese einer Modellverbindung für Tolyporphin A

Veröffentlichungsdatum
2003-09-29
Autoren
Manski, René  
Betreuer
Montforts, Franz-Peter  
Gutachter
Stohrer, Wolf-Dieter  
Zusammenfassung
Tolyporphin A was isolated by Moore and co-workers from the lipophilic extract of the blue green mircoalga Tolypothrix nodosa in 1992. This structurally unique porphyrin was found to reverse mulitidrug resistance (MDR) in a vinblastine resistant population of human ovarian adenocarinoma cells. Subsequently, 10 additional tolyporphins (B-K) were isolated from the same biological source. It was found that these additional structures to possess varying degrees of anti-MDR activity.Aim of this thesis was the total synthesis of a model compound for tolyporphin A. The envisaged model compound reflects the basic structural elements of naturally occurring tolyporphin A including stereochemistry. Only two pyrane moieties of tolyporphin A were replaced in the model structure by simple acetic acid residues.The basic synthetic strategy developed for the model compound should also open an access to tolyporphin A itself.
Schlagwörter
Tolyporphin A, pyrrols, sonogashira coupling, multidrug resistence (MDR)
Institution
Universität Bremen  
Fachbereich
Fachbereich 02: Biologie/Chemie (FB 02)  
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Deutsch
Dateien
Lade...
Vorschaubild
Name

E-Diss761_Manski2.pdf

Size

1.19 MB

Format

Adobe PDF

Checksum

(MD5):90c15045672621e0a34b19f19f141663

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science

  • Datenschutzbestimmungen
  • Endnutzervereinbarung
  • Feedback schicken