Control of Stereoselectivity in Heterogeneous Catalysis by Functionalization of Pt Nanoparticles with alpha-Amino Acids
File | Description | Size | Format | |
---|---|---|---|---|
00107467-1.pdf | 4.88 MB | Adobe PDF | View/Open |
Other Titles: | Steuerung von Stereoselektivität in der heterogenen Katalyse durch Funktionalisierung von Pt Nanopartikeln mit alpha-Aminosäuren | Authors: | Sulce, Anda ![]() |
Supervisor: | Kunz, Sebastian | 1. Expert: | Kunz, Sebastian | Experts: | Bäumer, Marcus | Abstract: | The asymmetric hydrogenation of ß-keto esters over amino acid-functionalized Pt nanoparticles (NPs) was explored. The investigated catalysts are chemoselective and stereoselective due to specific ligand-reactant interactions between ligands and reactants. Based on structure-selectivity relationships, the previously for L-proline-functionalized Pt NPs suggested ligand-reactant interaction model could be validated, extended to other amino acid ligands, and further refined. Nonlinear effect analysis revealed that in most cases the stereoselectivity is determined mainly by a 1:1 ligand-reactant interaction. Adjusting the interactions between ligands and reactants allowed to improve the stereoselectivity up to an enantiomeric excess over 80%. Most amino acid ligands not only induce selectivity but also enhance the reaction rate. The results of a systematic kinetic study provided an important contribution to the understanding of the reaction mechanism. |
Keywords: | Ligand-functionalized nanoparticles; ligand-reactant interactions; nonlinear effects; stereoselective heterogeneous catalysis; asymmetric hydrogenation; ligand acceleration effect; reaction kinetics | Issue Date: | 14-Jun-2019 | Type: | Dissertation | Secondary publication: | no | URN: | urn:nbn:de:gbv:46-00107467-16 | Institution: | Universität Bremen | Faculty: | Fachbereich 02: Biologie/Chemie (FB 02) |
Appears in Collections: | Dissertationen |
Page view(s)
381
checked on Apr 2, 2025
Download(s)
254
checked on Apr 2, 2025
Google ScholarTM
Check
Items in Media are protected by copyright, with all rights reserved, unless otherwise indicated.