Skip navigation
SuUB logo
DSpace logo

  • Home
  • Institutions
    • University of Bremen
    • City University of Applied Sciences
    • Bremerhaven University of Applied Sciences
  • Sign on to:
    • My Media
    • Receive email
      updates
    • Edit Account details

Citation link: https://nbn-resolving.de/urn:nbn:de:gbv:46-00102074-16
00102074-1.pdf
OpenAccess
 
copyright

Interaction of Siglec-4 with naturally occurring and synthetic glycoconjugates


File Description SizeFormat
00102074-1.pdf9.59 MBAdobe PDFView/Open
Other Titles: Interaktionen von Siglec-4 mit natürlich vorkommenden und synthetischen Glykokonjugaten
Authors: Koliwer-Brandl, Hendrik 
Supervisor: Kelm, Sørge  
1. Expert: Kelm, Sørge  
Experts: Dringen, Ralf
Abstract: 
The aim of this work has been to provide insights into the structure-function relationship of Siglec-4 binding naturally occurring sialic acids as well as synthetic sialic acid derivatives. Structural information of the Siglec binding site and its interactions with glycoconjugates were obtained from homology modeling of the sialic acid binding domain and molecular docking calculations with several sialosides. Furthermore, the interaction of chemically synthesized sialic acid derivatives with improved inhibitory potential for Siglec-4 as well as the interactions of Siglec-2 and Siglec-4 with oligo- and even polyvalent sialoglycoconjugates occurring in bovine milk are described. Finally, the potential of enzymatic sialylation using trans-sialidases from Trypanosoma congolense has been investigated demonstrating that trans-sialidases can sialylate glycoproteins like asialofetuin to sufficiently high density for Siglec-4 recognition.
Keywords: Siglec; CD22; MAG; trans-sialidase; sialoside; glycoconjugates; milk; HMOS; ganglioside; homology modeling; ligand docking; inhibition
Issue Date: 14-Jun-2011
Type: Dissertation
Secondary publication: no
URN: urn:nbn:de:gbv:46-00102074-16
Institution: Universität Bremen 
Faculty: Fachbereich 02: Biologie/Chemie (FB 02) 
Appears in Collections:Dissertationen

  

Page view(s)

210
checked on May 11, 2025

Download(s)

49
checked on May 11, 2025

Google ScholarTM

Check


Items in Media are protected by copyright, with all rights reserved, unless otherwise indicated.

Legal notice -Feedback -Data privacy
Media - Extension maintained and optimized by Logo 4SCIENCE