Untersuchung der Rolle von IRF-7 bei der Suppression der Hämatopoese durch das Hepatitis A-Virus

The interferon regulatory factor 7 (IRF-7) plays an important role in the monocyte (MO)-to-macrophage (MAC) differentiation. This work shows that hepatitis A virus (HAV) suppresses the activation of IRF-7 by blocking its phosphorylation and in the following its nuclear translocalisation. It is hypothesed that this ability of HAV causes the perturbance of the MO-to-MAC maturation observed in HAV infections.