Dotzauer, AndreasLelke, MichaelaMichaelaLelke2020-03-102020-03-102010-07-01https://media.suub.uni-bremen.de/handle/elib/2834The central domain of the 200-kDa Lassa virus L protein is a putative RNA-dependent RNA polymerase. N- and C-terminal domains may harbor enzymatic functions important for viral mRNA synthesis, including capping enzymes or cap-snatching endoribonucleases. In this work it was shown that the N-terminal region in L protein is important for mRNA, but not for genome synthesis. Bioinformatics and cell biological experiments lend support to the hypothesis that this region could be part of a cap-snatching enzyme.deinfo:eu-repo/semantics/openAccessLassa virusendonucleasecapping570Dissertationurn:nbn:de:gbv:46-diss000119768