Pigeot-Kübler, IrisKoehne-Voss, Stephan2020-03-092020-03-092005-11-21https://media.suub.uni-bremen.de/handle/elib/2193A numerical procedure for convolution and deconvolution of pharmacokinetic data is looked at as a statistical estimation problem. Estimators for the input-and response function based on a point-area convolution method are derived and their asymptotical properties are discussed. Several approaches to estimate the asymptotic variance of the estimators including jackknife and bootstrap techniques are discussed. A simulation study to investigate the finite sample performance of the estimators is presented.deinfo:eu-repo/semantics/openAccessconvolutiondeconvolutioninput functionresponse functionpharmacokineticestimation500Dissertationurn:nbn:de:gbv:46-diss000102149