Bartels, JuliaJuliaBartelsBatista, Artur GuedertArtur GuedertBatistaKroll, StephenStephenKrollMaas, MichaelMichaelMaasRezwan, KuroschKuroschRezwan2023-09-182023-09-182018-10-2303767388https://media.suub.uni-bremen.de/handle/elib/717310.26092/elib/2493In this study, we present hydrophobic yttria-stabilized zirconia capillary membranes conditioned for virus filtration. These macroporous ceramic filters (d50 = 150 nm) efficiently extract viruses regardJess of their surface charge with high throughput rates. For hydrophobic functionalization of the ceramic membranes we used two different silanes, n-hexyltriethoxysilane (HTS, C6-chain) and n-octyltriethoxysilane (OTS, C8-chain), in three different molarities. The virus retention of the membranes is tested in dead-end mode by intracapillary virus feeding using two small bacteriophages as model species: MS2 and PhiX174. Virus retention increases most strongly for hydrophobic capillaries functionalized with 0.05 M OTS, showing a virtually complete retention with log-reduction values (LRVs) of - 9 for both bacteriophages compared to the non-functionalized membrane with LRVs of 0.3 ± 0.1 for MS2 and 3.4 ± 0.2 for PhiXl 74. The functionalized membranes allow a high membrane flux of - 150 L/(m2hbar), with throughput rates up to - 400 L/(m2 h) while maintaining high filtration efficiency. Even under varying feed conditions using only mono- or divalent salt ions or pH values ranging from 3 to 9, retention capacities of the capillary membranes are high. Accordingly, such hydrophobic ceramic membranes offer a versatile alternative to conventional polymeric membranes for virus removal with greatly improved membrane flux.8enCC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)https://creativecommons.org/licenses/by-nc-nd/4.0/Mimenima620Artikel/Aufsatzurn:nbn:de:gbv:46-elib71734