Untersuchung der Rolle von IRF-7 bei der Suppression der Hämatopoese durch das Hepatitis A-Virus

Vallbracht, AngelikaHändschke, Sonja2020-03-092020-03-092009-11-11https://media.suub.uni-bremen.de/handle/elib/2726The interferon regulatory factor 7 (IRF-7) plays an important role in the monocyte (MO)-to-macrophage (MAC) differentiation. This work shows that hepatitis A virus (HAV) suppresses the activation of IRF-7 by blocking its phosphorylation and in the following its nuclear translocalisation. It is hypothesed that this ability of HAV causes the perturbance of the MO-to-MAC maturation observed in HAV infections.deinfo:eu-repo/semantics/openAccessinterferon regulatory factor 7IRF-7monocytemacrophagehematopoiesishepatitis A-virusHAV570Untersuchung der Rolle von IRF-7 bei der Suppression der Hämatopoese durch das Hepatitis A-VirusAnalysis of the contribution of IRF-7 to the suppression of hematopoiesis mediated by the Hepatitis A-virusDissertationurn:nbn:de:gbv:46-diss000116257