Prognoseparameter bei soliden Tumoren und Systemerkrankungen

Abstract

Solid tumors and malignant systemic diseases are two of the most severe burdens of the world. The incidence rate of more than 11 million cases per year is considerably high. For this reason new methods and knowledge are required. By the methods developed and relations given in this dissertation a big step forward in cancer research is realized. New possibilities to measure gene expression of pseudogene rich gene families were established. Furthermore multifaceted gene expression profiles for prognostic parameters such as HMGA2, HMGB1, uPA, PAI1, Her2neu were established, analysed, and discussed. The presented work underlines the significantly high influence of HMG proteins in cancer development. New approaches and starting points for further analyses are identified and are the basis to upgrade diagnosis, prognosis, and therapy of cancer patients.