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  4. microRNAs as novel biomarkers for patients with testicular germ cell tumours
 
Zitierlink DOI
10.26092/elib/302

microRNAs as novel biomarkers for patients with testicular germ cell tumours

Veröffentlichungsdatum
2019-06-25
Autoren
Spiekermann, Meike  
Betreuer
Belge, Gazanfer  
Gutachter
Koch, Michael  
Zusammenfassung
Testicular cancer is the most common malignancy in men aged 14 - 44 years. In clinical management of testicular germ cell tumours (TGCTs), measurement of biomarkers is essential. However, only <60 % of cases show increased levels of the classical markers (AFP, b-HCG, and LDH) and novel tumour markers are urgently needed. microRNAs (miRNAs) are small non-coding RNA molecules and play an important role in biological processes. They are dysregulated in cancer and expression profiles might be useful biomarkers. The aim of this thesis was to validate the application of miRNAs of two clusters (miR-371-3 and miR-302/367) as novel serum markers for TGCTs. In each of the three studies, expression analyses demonstrated that serum levels of miR-371 fulfil all prerequisites for a valuable biomarker and the large-scale multicentre study showed 88.7 % sensitivity and 93.4 % specificity. Further studies are necessary to determine the miR-371 expression in metastasised patients especially during follow-up.
Schlagwörter
biomarkers

; 

testicular germ cell tumours

; 

microRNAs

; 

serum
Institution
Universität Bremen  
Fachbereich
Fachbereich 02: Biologie/Chemie (FB 02)  
Dokumenttyp
Dissertation
Zweitveröffentlichung
Nein
Sprache
Englisch
Dateien
Lade...
Vorschaubild
Name

00108628-1.pdf

Size

9.56 MB

Format

Adobe PDF

Checksum

(MD5):90c06a96fe33deca3ef94b48976f7f61

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