Chromatographische Untersuchung der Wechselwirkung von Arzneimitteln und Borclusterverbindungen mit Lipidmembranen

Immobilized liposome chromatography (ILC) was utilized to investigate the interaction of drugs, chemicals and dodecaborate cluster compounds with liposomes. Dodecaborate cluster compounds were found to interact with hydrophilic column materials (Superdex 200, Sepharose 4B, Sephadex G50 and Sephadex G100). Silica gel showed no or very weak interaction with dodecaborate cluster compounds, and the modified silica gel was used to investigate the interation of dodecaborate cluster compounds with lipid membranes.