Untersuchung der Rolle von IRF-7 bei der Suppression der Hämatopoese durch das Hepatitis A-Virus
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| Other Titles: | Analysis of the contribution of IRF-7 to the suppression of hematopoiesis mediated by the Hepatitis A-virus | Authors: | Händschke, Sonja | Supervisor: | Vallbracht, Angelika | 1. Expert: | Vallbracht, Angelika | Experts: | Kazmierczak, Bernd | Abstract: | The interferon regulatory factor 7 (IRF-7) plays an important role in the monocyte (MO)-to-macrophage (MAC) differentiation. This work shows that hepatitis A virus (HAV) suppresses the activation of IRF-7 by blocking its phosphorylation and in the following its nuclear translocalisation. It is hypothesed that this ability of HAV causes the perturbance of the MO-to-MAC maturation observed in HAV infections. |
Keywords: | interferon regulatory factor 7; IRF-7; monocyte; macrophage; hematopoiesis; hepatitis A-virus; HAV | Issue Date: | 11-Nov-2009 | Type: | Dissertation | Secondary publication: | no | URN: | urn:nbn:de:gbv:46-diss000116257 | Institution: | Universität Bremen | Faculty: | Fachbereich 02: Biologie/Chemie (FB 02) |
| Appears in Collections: | Dissertationen |
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