Eine neue Methode für regioselektive Einführung von Phosphinaten in fluorierte Diketone und Imine

Abstract

The aim of this thesis was to investigate the reactivity of ethyl methylphosphinate and ethyl phenylphosphinate in reactions with fluorinated diketones, fluorinated and nonfluorinated cyclic imines and trifluoromethylpyruvate. The dehydration of phosphinylated ketones led to formation of fluorinated phosphinylated enones, which can be used as versatile applicable building blocks in organic chemistry.Recently, there has been considerable interest in the derivatives of hydroxybisphosphonates because of their biological properties and medical application. Herein we presented a first attempt to synthesize a new class of fluorinated bisphosphinates. Unfortunately, these products are sensitive to moisture and undergo the phosphinate-phosphonate rearrangement quickly.