Der Conditional Synergy Index --Ein Maß zur Bestimmung einer Gen-Gen-Interaktion basierend auf graphischen Modellen

Abstract

In genetic studies of complex diseases, it is important to identify and qualify gene-gene interactions. Interaction is often defined as deviance from genetic additive effects. But this statistical definition needs not to reflect the genes' biological interactions. I propose a new method to detect gene-gene interaction that exploits the concept of synergy and antagonism, which is said to capture biological relationships. The conditional synergy index (CSI) classifies and quantifies interaction on the penetrance scale. The general theory under two-locus disease models is developed. The index assumes a cohort design and genotypes to be dichotomized into risk-genotypes (exposed) and non-risk-genotypes (unexposed) but it does not assume the loci to be in linkage equilibrium. In simulation studies the performance of the CSI, its estimator and variance is investigated and compared to the performance of various epidemiological interaction measure like e.g. Rothman's syngergy index and to appropriate bootstrap estimators. The results exhibit that in contrast to common interaction measures, only the CSI is adequat to detect interaction on the penetrance scale. However, the proposed estimator of the CSI shows a slow convergence.