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Citation link: https://nbn-resolving.de/urn:nbn:de:gbv:46-diss000102149
00010214.pdf
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Schätzung der Input- und Response-Funktion bei numerischer Konvolution und Dekonvolution im Rahmen pharmakokinetischer Untersuchungen


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Other Titles: Estimation of input and response functions when performing numerical convolution and deconvolution with pharmacokinetic data
Authors: Koehne-Voss, Stephan 
Supervisor: Pigeot-Kübler, Iris
1. Expert: Pigeot-Kübler, Iris
Experts: Nörtersheuser, Peter 
Abstract: 
A numerical procedure for convolution and deconvolution of pharmacokinetic data is looked at as a statistical estimation problem. Estimators for the input-and response function based on a point-area convolution method are derived and their asymptotical properties are discussed. Several approaches to estimate the asymptotic variance of the estimators including jackknife and bootstrap techniques are discussed. A simulation study to investigate the finite sample performance of the estimators is presented.
Keywords: convolution; deconvolution; input function; response function; pharmacokinetic; estimation
Issue Date: 21-Nov-2005
Type: Dissertation
Secondary publication: no
URN: urn:nbn:de:gbv:46-diss000102149
Institution: Universität Bremen 
Faculty: Fachbereich 03: Mathematik/Informatik (FB 03) 
Appears in Collections:Dissertationen

  

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