Schätzung der Input- und Response-Funktion bei numerischer Konvolution und Dekonvolution im Rahmen pharmakokinetischer Untersuchungen
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| 00010214.pdf | 1.94 MB | Adobe PDF | View/Open | |
| 00010214.pdf | 1.94 MB | Adobe PDF | View/Open |
| Other Titles: | Estimation of input and response functions when performing numerical convolution and deconvolution with pharmacokinetic data | Authors: | Koehne-Voss, Stephan | Supervisor: | Pigeot-Kübler, Iris | 1. Expert: | Pigeot-Kübler, Iris | Experts: | Nörtersheuser, Peter | Abstract: | A numerical procedure for convolution and deconvolution of pharmacokinetic data is looked at as a statistical estimation problem. Estimators for the input-and response function based on a point-area convolution method are derived and their asymptotical properties are discussed. Several approaches to estimate the asymptotic variance of the estimators including jackknife and bootstrap techniques are discussed. A simulation study to investigate the finite sample performance of the estimators is presented. |
Keywords: | convolution; deconvolution; input function; response function; pharmacokinetic; estimation | Issue Date: | 21-Nov-2005 | Type: | Dissertation | Secondary publication: | no | URN: | urn:nbn:de:gbv:46-diss000102149 | Institution: | Universität Bremen | Faculty: | Fachbereich 03: Mathematik/Informatik (FB 03) |
| Appears in Collections: | Dissertationen |
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