Production of ceramic membranes with different pore sizes for virus retention

Abstract

Porous ceramic capillary membranes made of yttria-stabilised zirconia (YSZ) are presented, which are conditioned for virus filtration by varying the initial YSZ particle size. Compared to polymeric membranes, ceramic membranes offer remarkable advantages for filtration processes as they show excellent chemical, thermal and mechanical stability and can easily be cleaned by backflushing. YSZ powders with different particle sizes (30 nm, 40 nm and 90 nm) are individually and mixed processed by extrusion, dried and finally sintered at 1050 °C for 2 h. The sintered YSZ capillaries are characterised by microstructural analysis including Hg-porosimetry, BET analysis and 3-point bending tests. By increasing the initial YSZ particle size, increased average membrane pore sizes ranging from 24 nm to 146 nm are obtained. Mechanically stable membranes are provided showing high open porosities of ∼45% and ∼36% for capillaries composed of single and mixed YSZ powders, respectively. By increasing the membrane pore size, reduced virus retention capacities in combination with increased water permeate fluxes are achieved. Capillaries made of YSZ-40 nm ensure both, log reduction values (LRV) ≥ 4 for small model bacteriophages MS2 and PhiX174 and high water permeate fluxes (∼30 L/(m2 hbar)), being suitable for sustainable virus filtration as requested by the World Health Organisation (WHO) and the United States Environmental Protection Agency (USEPA). Due to long-term virus filtration for two weeks, membrane pore plugging is successfully avoided by iterative backflushing and relatively high membrane fluxes in combination with requested LRV 4 level fulfilling the virus filter criterion are achieved.