Hydrophobic ceramic capillary membranes for versatile virus filtration
Date Issued
2018-10-23
Abstract
In this study, we present hydrophobic yttria-stabilized zirconia capillary membranes conditioned for virus filtration. These macroporous ceramic filters (d50 = 150 nm) efficiently extract viruses regardJess of their surface charge with high throughput rates. For hydrophobic functionalization of the ceramic membranes we used two different silanes, n-hexyltriethoxysilane (HTS, C6-chain) and n-octyltriethoxysilane (OTS, C8-chain), in three different molarities. The virus retention of the membranes is tested in dead-end mode by intracapillary virus feeding using two small bacteriophages as model species: MS2 and PhiX174. Virus retention increases most strongly for hydrophobic capillaries functionalized with 0.05 M OTS, showing a virtually complete retention with log-reduction values (LRVs) of - 9 for both bacteriophages compared to the non-functionalized membrane with LRVs of 0.3 ± 0.1 for MS2 and 3.4 ± 0.2 for PhiXl 74. The functionalized membranes allow a high membrane flux of - 150 L/(m2hbar), with throughput rates up to - 400 L/(m2 h) while maintaining high filtration efficiency. Even under varying feed conditions using only mono- or divalent salt ions or pH values ranging from 3 to 9, retention capacities of the capillary membranes are high. Accordingly, such
hydrophobic ceramic membranes offer a versatile alternative to conventional polymeric membranes for virus removal with greatly improved membrane flux.
hydrophobic ceramic membranes offer a versatile alternative to conventional polymeric membranes for virus removal with greatly improved membrane flux.
Subjects
Mimenima
Publisher
Elsevier
Institution
Type
journal article
Journal/Edited collection
Band
570-571
Start page
85
End page
92
Page number
8
Secondary publication
Yes
Document version
Postprint
Language
English
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Name
J. Bartels, A.G. Batista, S. Kroll, M. Maas, K. Rezwan, Hydrophobic ceramic capillary membranes for versatile virus filtration_2019_accepted version.pdf
Size
1.5 MB
Format
Adobe PDF
Checksum
(MD5):4b128231c33fa35f756b0500026f2095