Organic Electrochemical Transistors and Foreign Body Reaction: First Steps Toward Long-Term Implantable Biosensing
Date Issued
2026-03
Author(s)
Frulani De Paula Barbosa Henrique
Korea Advanced Institute of Science and Technology, Korea Institute of Energy Research, Max Planck Institute for Polymer Research, POSCO, Universidade Federal de Itajubá, Universidade de São Paulo Escola de Engenharia de São Carlos, University of Bremen
Kumar, Ankush
Van Den Driesche Sander
Delft University of Technology, University of Bremen, Vienna University of Technology
Abstract
Organic Electrochemical Transistors (OECT) have been widely used to detect a myriad of analytes and signals, ranging from glucose content in sweat to brain epileptiform activity. Due to their biocompatibility, small footprint, conformability, and high signal amplification, OECTs can not only be used in wearable, but also in implanted sensor systems, providing superior signal quality. However, although there is a risk of triggering the Foreign Body Reaction (FBR) with implantation, FBR impact on OECTs has rarely been discussed. Therefore, here we evaluate the effect of the FBR fibrotic response on OECT performance, i.e. when the OECT is covered by protein layers, in vitro. In more detail, we analyze poly(3,4-ethylenedioxythiophene):poly (styrene-sulfonate) (PEDOT:PSS) based OECTs and intentionally cover their channels with protein layers commonly formed during FBR, such as albumin, collagen and fibrinogen. Despite slightly increasing devices' switching time, proteins do not hamper their operation. Further coverage by yeast cells as a proof of concept of wound healing process also did not jeopardize OECT functioning, indicating devices could resist the FBR fibrotic response without anti-FBR strategies.
Publisher
Wiley
Institution
Type
journal article
Journal/Edited collection
Advanced Electronic Materials
ISSN
2199-160X
Band
12
Issue
7
Language
English