Untersuchungen zur Genetik von Speicheldrüsentumoren
Date Issued
2009-11-26
Author(s)
Supervisors
Referees
Abstract
We have analyze the recently for mucoepidermoid carcinoma (MEC) and Warthin's tumor (WAT) described gene fusion CRTC1-MAML2 for its diagnostic potential as biomarker and to find out if an aberrant HMGA2 expression level influence tumorgenesis of MECs. Our studies have shown that a CRTC1-MAML2 test is a powerful tool for diagnosis and prognosis of MECs. The fusion correlates with a low- or intermediate-grade of the tumor and is associated with a favorable prognosis. CRTC1-MAML2 negative tumors were mainly found in high-grade tumors and show a significant increased HMGA2 level. These data raise doubts about the correct classification of MECs into low-, intermediate- and high-grade tumors. In our opinion the present classification of MECs includes two subgroups: A huge group of "true-MECs" with the CRTC1-MAML2 fusion, with a moderate aggressiveness and furthermore a group of morphological heterogeneous tumors lacking this fusion and with an aberrantly high HMGA2 expression level.
Subjects
Mucoepidermoid carcinoma
;
Warthin's tumor
;
CRTC1-MAML2
;
HMGA2
;
molecular biomarker
;
prognostic significance
Institution
Type
Dissertation
Secondary publication
No
Language
English
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